Purpose: Considering the important function of elements such as cash holdings and social responsibility in the realm of accounting studies, the study of factors affecting the relationship between them is important. Therefore, the main purpose of this study is investigating the moderating role of systematic risk and corporate governance on the relationship between social responsibility and cash holding. Methods: In order to reach the objectives of the study, 118 firms accepted in Tehran Stock Exchange between the years 2012 and 2017 have been selected, and based on compositional data analysis method, the hypotheses of the study have been tested. Results: Based on the results of statistical tests, it has been found that systematic risk has been able to affect and increase the impact of social responsibility on the cash holdings ؛ however, the moderating role of corporate governance on the relationship between social responsibility and cash holding was verified at 90% confidence level. Conclusion: In order to protect stakeholders’ ؛ rights, companies that care about their duties of social responsibility need to hold more cash. Accordingly, the increase in systematic risk increases the need to take extra cash. It also seems that corporate governance reduces the need for cash holdings in companies, and this way it is the best strategy for companies interested in investing in social issues. Contribution: Investigating the moderating effect of corporate governance, along with systematic risk factor, can have information content in examining the effect of social responsibility on cash holding.